Dupixent® and Reported Cancer Risks

Dupixent® (dupilumab) is a prescription injection manufactured by Sanofi and Regeneron and first approved by the FDA in 2017. It is commonly prescribed for patients of all ages — including children as young as six months old — with moderate-to-severe eczema (atopic dermatitis), asthma, chronic sinusitis with nasal polyps, and eosinophilic esophagitis. For many people, it provided relief where other medications had failed.

In recent years, however, Dupixent® has been linked to cutaneous T-cell lymphoma (CTCL), a rare and serious form of non-Hodgkin lymphoma. Studies published in 2024 and 2025 suggest that Dupixent® patients may face a 300% higher risk of developing CTCL yet manufacturers never warned healthcare providers or patients about this risk. 

Understanding Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma is a rare cancer of the immune system that begins in the skin. At first, it can look almost the same as eczema, with red or scaly patches. Over time, it may turn into thicker lesions or tumors, and in advanced stages it can spread to lymph nodes and internal organs.

Because CTCL often begins with skin symptoms that closely resemble eczema or psoriasis, it is often misdiagnosed. Tragically, this also means that some patients diagnosed with eczema may have had undetected CTCL when they started Dupixent®. In those cases, the drug may have hidden the cancer’s early signs or delayed a proper diagnosis.

Why Lawsuits Are Being Filed

Patients and families across the country are pursuing legal claims against manufacturers Sanofi and Regeneron. These lawsuits allege that:

  • Dupixent® was marketed without adequate warnings about the risk of CTCL.
  • The similarity between eczema and CTCL symptoms made timely diagnosis difficult, a problem made worse by the lack of warnings by the manufacturers.
  • Patients lost the opportunity for closer monitoring, testing, and treatment.

Drug manufacturers are being held accountable for their failure to warn patients about the harm that their drugs could cause.

What Patients and Parents Should Do Next

Patients who have taken Dupixent® and later been diagnosed with cutaneous T-cell lymphoma should take the following steps:

  • Speak with their doctor about their diagnosis and treatment history. If symptoms persist, ask whether a biopsy or additional testing is appropriate.
  • Gather medical records showing when Dupixent® was prescribed, what symptoms were present, and when CTCL was diagnosed.
  • Consult with a reputable attorney to understand legal rights and filing deadlines, which vary by state.

Taking action promptly can help protect your ability to seek compensation and hold drug manufacturers accountable.

Contact Us Online

Team Leaders

Keith E. Donovan
Managing Partner
Matthew R. Fogg
Partner
Ashley C. Curran
Associate

Status of Dupixent® Litigation

Dupixent® cases are now underway. Individual lawsuits have now been filed, and we expect the number of cases to rise significantly as patients and their families learn about the connection between Dupixent® and cancer.

At Morris James, our attorneys are currently investigating emerging Dupixent® claims in multiple states. We are here to help families hurt by negligent drug manufacturers and advise them about their legal options.

Impact on Patients and Families

A diagnosis of cutaneous T-cell lymphoma can be devastating. Treatment may involve radiation, chemotherapy, immunotherapy, or stem cell transplants. Even when managed, the disease can recur or progress, requiring expensive medical interventions, lifelong care, and exhausting vigilance.

For families, the burden extends beyond medical treatment. Patients may be unable to work or may face reduced earning capacity. Out-of-pocket medical expenses can accumulate quickly. The emotional toll of coping with a cancer diagnosis, while also questioning whether it could have been prevented with better warnings, can be overwhelming.

Lawsuits are one way for patients and families to pursue accountability and financial recovery for these burdens.

Dupixent Lawsuits FAQs

What is cutaneous T-cell lymphoma (CTCL)?

CTCL is a rare cancer that starts in the body’s immune system but shows up on the skin. It can look like eczema at first, with red, scaly, itchy patches. Over time, it can spread, forming thicker lesions, affecting the lymph nodes, and, in advanced cases, spreading to other organs. Because the early symptoms mimic common skin conditions, CTCL is often misdiagnosed or diagnosed late.

How is Dupixent® connected to CTCL?

Studies published in 2024 and 2025 have shown that patients taking Dupixent® are significantly more likely to develop CTCL compared to those who are not. Doctors believe Dupixent® may unmask undiagnosed CTCL by suppressing eczema-like symptoms, making the cancer more visible only after it has progressed. Other research suggests the drug may play a role in accelerating the disease. The manufacturers of Dupixent®, Sanofi and Regeneron, failed to communicate these risks to patients or prescribers.

What warning signs should families watch for?

If your child or family member taking Dupixent® is not improving, or if their skin symptoms or rash seem to worsen, spread, or change in appearance, this can be a red flag. Other warning signs include unexplained itching, new nodules or lesions, swollen lymph nodes, or weight loss. Families should ask for a biopsy and further testing if symptoms do not improve.

Does scientific evidence support a connection between CTCL and Dupixent®?

A growing number of peer‑reviewed studies have looked closely at the connection between Dupixent® and CTCL.

One 2024 study led by Hasan and colleagues found that patients with atopic dermatitis who were treated with Dupixent® had more than a threefold higher risk of developing CTCL, twofold after adjusting for age, sex, and certain other factors.

Another 2024 analysis by Mandel et al. using TriNetX data reported a similarly elevated risk when comparing Dupixent® users to non‑users.

In 2025, Ma and colleagues examined asthma patients who started Dupixent® and found that the risk of CTCL was more than four times higher compared to those treated with other asthma drugs. The risk was even greater for certain T‑ and NK‑cell lymphomas after longer use.

Earlier reports, including a 2019 article in the Journal of the American Academy of Dermatology, documented cases where CTCL symptoms accelerated while patients were on Dupixent®. Additional case reports continue to warn that the drug may unmask or worsen hidden lymphomas mistaken for eczema.

Who can file a Dupixent® lawsuit?

You may be eligible if you or a loved one were prescribed Dupixent® and later diagnosed with CTCL. This includes parents or guardians filing on behalf of a minor child or families who lost a loved one. To support your claim, you will need to show medical records showing Dupixent® use, the timing of symptoms and diagnosis, and whether cancer was discovered after treatment began. Our Dupixent® Lawsuits attorneys can help you gather this information.

Can children file a Dupixent lawsuit?

Yes. Dupixent® has been FDA-approved for pediatric patients as young as six months old, and children make up a significant portion of those who have been prescribed it for moderate-to-severe eczema. If your child was prescribed Dupixent® and later developed CTCL or another T-cell lymphoma, you may be able to bring a claim on their behalf. A parent or legal guardian typically brings the lawsuit for a minor child. The same evidence matters — medical records showing Dupixent® use, the timing of the diagnosis, and the progression of symptoms. Contact our Mass Torts attorneys for a free consultation to discuss your child's situation.

What kinds of compensation are available?

Patients and families may be able to recover the costs of past and future medical treatment, lost income, and reduced earning capacity. Compensation may also be available for the pain, suffering, and emotional distress caused by the diagnosis. If your loved one died as a result of their CTCL, you may be able to seek damages for wrongful death, including loss of companionship and financial support.

Do these cases always go to trial?

Not always. Some cases resolve through negotiated settlements. But when drug manufacturers deny responsibility, litigation may be necessary. At Morris James, we are trial-ready and tested. If going to court is what it takes to protect our clients, we are prepared to stand before a jury.

How long do I have to file a lawsuit?

Every state has its own statute of limitations, which sets a deadline for filing. In Delaware, these cases should typically be filed within two years of the injury or diagnosis but, because these deadlines vary, it is critical to speak with a lawyer as soon as possible to avoid losing your right to bring a claim.

How much does it cost to pursue a case?

At Morris James, there are no upfront costs. We represent Dupixent® clients on a contingency fee basis, which means we only get paid if we recover compensation for you. Families can focus on medical care and healing while we handle the legal fight.

If you or someone you love took Dupixent® and was later diagnosed with cutaneous T-cell lymphoma, now is the time to act. At Morris James, we have decades of experience holding drug manufacturers accountable. Call us today at 302.655.2599 or submit our online form below for a free, confidential consultation.

Connect with the Mass Torts Litigation Group at Morris James

Thank you for your interest in Morris James. Please provide us with the following information so that we can connect you with the appropriate attorney.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.